Beginning of main content
  • Destinations
    South America
  • Departure Ports
    Any Port
  • Departure Date Range
    Any Date
  • Adults (25+)
    2

398 Cruises

Show Search Filters
Loading
from
to

Questions? 1-877-533-6060

  • 3-Night South America Cruise

    3-Night South America Cruise
    MSC Cruises
    MSC Fantasia
    Depart: Tue, Nov 26, 2019
    Returns: Fri, Nov 29, 2019
    Depart – Santos, Brazil
    • Porto Belo, Brazil
    • Balneario Camboriu, Brazil
    Returns – Santos, Brazil
    Santos, Brazil - Porto Belo, Brazil - Balneario Camboriu, Brazil - Santos, Brazil
    from
    C$460*
    *restrictions apply
    Taxes of C$56 Included


  • 3-Night South America Cruise

    3-Night South America Cruise
    MSC Cruises
    MSC Seaview
    Depart: Fri, Mar 6, 2020
    Returns: Mon, Mar 9, 2020
    Depart – Santos, Brazil
    • Balneario Camboriu, Brazil
    • At Sea
    Returns – Santos, Brazil
    Santos, Brazil - Balneario Camboriu, Brazil - At Sea - Santos, Brazil
    from
    C$682*
    *restrictions apply
    Taxes of C$56 Included
  • 3-Night South America Cruise

    3-Night South America Cruise
    MSC Cruises
    MSC Sinfonia
    Depart: Fri, Dec 13, 2019
    Returns: Mon, Dec 16, 2019
    Depart – Santos, Brazil
    • Itajai, Brazil
    • At Sea
    Returns – Montevideo, Uruguay
    Santos, Brazil - Itajai, Brazil - At Sea - Montevideo, Uruguay
    from
    C$465*
    *restrictions apply
    Taxes of C$56 Included
  • 6-Night South America Cruise

    6-Night South America Cruise
    MSC Cruises
    MSC Fantasia
    Depart: Sun, Jan 26, 2020
    Returns: Sat, Feb 1, 2020
    Depart – Rio de Janeiro, Brazil
    • Buzios, Brazil
    • At Sea
    • Salvador, Brazil
    • Ilheus, Brazil
    • At Sea
    Returns – Rio de Janeiro, Brazil
    Rio de Janeiro, Brazil - Buzios, Brazil - At Sea - Salvador, Brazil - Ilheus, Brazil - At Sea - Rio de Janeiro, Brazil
    from
    C$908*
    *restrictions apply
    Taxes of C$112 Included
  • 4-Night South America Cruise

    4-Night South America Cruise
    MSC Cruises
    MSC Seaview
    Depart: Mon, Dec 9, 2019
    Returns: Fri, Dec 13, 2019
    Depart – Santos, Brazil
    • Balneario Camboriu, Brazil
    • Porto Belo, Brazil
    • At Sea
    Returns – Santos, Brazil
    Santos, Brazil - Balneario Camboriu, Brazil - Porto Belo, Brazil - At Sea - Santos, Brazil
    from
    C$764*
    *restrictions apply
    Taxes of C$75 Included
  • 14-Night South America Cruise

    BEST
    VALUE*
    14-Night South America Cruise
    Norwegian Cruise Line
    Norwegian Star
    Depart: Sat, Dec 21, 2019
    Returns: Sat, Jan 4, 2020
    Depart – San Antonio, Chile
    • At Sea
    • Puerto Montt, Chile
    • Puerto Chacabuco, Chile
    • Chilean Fjords, Chile
    • At Sea
    • Strait of Magellan, Chile
    • Punta Arenas, Chile
    • Beagle Channel (Argentina/Chile)
    • Ushuaia, Argentina
    • Cape Horn, Chile
    • Port Stanley, Falkland Islands (Malvinas)
    • At Sea
    • Puerto Madryn, Argentina
    • At Sea
    • Montevideo, Uruguay
    Returns – Buenos Aires, Argentina
    San Antonio, Chile - At Sea - Puerto Montt, Chile - Puerto Chacabuco, Chile - Chilean Fjords, Chile - At Sea - Strait of Magellan, Chile - Punta Arenas, Chile - Beagle Channel (Argentina/Chile) - Ushuaia, Argentina - Cape Horn, Chile - Port Stanley, Falkland Islands (Malvinas) - At Sea - Puerto Madryn, Argentina - At Sea - Montevideo, Uruguay - Buenos Aires, Argentina
    Expedia® Extras* (Extras vary and apply to select staterooms and prices)
    • Take All Free! Open Bar, Dining, Excursions, WiFi - Ends 7/23
    • FREE Drinks, Dining, Excursion Credit & WiFi - Ends 7/23
    • FREE WiFi & Excursion Credit - Ends 7/23
    • show more 
    from
    C$2632*
    *restrictions apply
    Taxes of C$491 Included
  • 13-Night South America Cruise

    13-Night South America Cruise
    Azamara Club Cruises
    Azamara Pursuit
    Depart: Sun, Dec 8, 2019
    Returns: Sat, Dec 21, 2019
    Depart – Buenos Aires, Argentina
    • Montevideo, Uruguay
    • At Sea
    • At Sea
    • Santos, Brazil
    • Paraty, Brazil
    • Buzios, Brazil
    • Rio de Janeiro, Brazil
    • Rio de Janeiro, Brazil
    • Rio de Janeiro, Brazil
    • At Sea
    • At Sea
    • Punta del Este, Uruguay
    Returns – Buenos Aires, Argentina
    Buenos Aires, Argentina - Montevideo, Uruguay - At Sea - At Sea - Santos, Brazil - Paraty, Brazil - Buzios, Brazil - Rio de Janeiro, Brazil - Rio de Janeiro, Brazil - Rio de Janeiro, Brazil - At Sea - At Sea - Punta del Este, Uruguay - Buenos Aires, Argentina
    Expedia® Extras* (Extras vary and apply to select staterooms and prices)
    • Sail Into Savings - up to 30% Off per person
    from
    C$2623*
    *restrictions apply
    Taxes of C$552 Included
  • 15-Night South America Cruise

    15-Night South America Cruise
    Celebrity Cruises
    Celebrity Eclipse
    Depart: Sat, Dec 21, 2019
    Returns: Sun, Jan 5, 2020
    Depart – Buenos Aires, Argentina
    • Buenos Aires, Argentina
    • Montevideo, Uruguay
    • Punta del Este, Uruguay
    • At Sea
    • At Sea
    • Puerto Madryn, Argentina
    • At Sea
    • Cape Horn, Chile
    • Ushuaia, Argentina
    • Punta Arenas, Chile
    • Strait of Magellan, Chile
    • Chilean Fjords, Chile
    • Puerto Montt, Chile
    • At Sea
    Returns – San Antonio, Chile
    Buenos Aires, Argentina - Buenos Aires, Argentina - Montevideo, Uruguay - Punta del Este, Uruguay - At Sea - At Sea - Puerto Madryn, Argentina - At Sea - Cape Horn, Chile - Ushuaia, Argentina - Punta Arenas, Chile - Strait of Magellan, Chile - Chilean Fjords, Chile - Puerto Montt, Chile - At Sea - San Antonio, Chile
    Expedia® Extras* (Extras vary and apply to select staterooms and prices)
    • Sail Your Way Savings Offer! Save up to $1000 per stateroom!
    • Sail Plus! FREE Drinks & WiFi
    • Sail Plus! FREE Drinks & Tips
    • show more 
    from
    C$2073*
    *restrictions apply
    Taxes of C$400 Included
  • 14-Night South America Cruise

    14-Night South America Cruise
    Holland America Line
    ms Amsterdam
    Depart: Mon, Sep 30, 2019
    Returns: Mon, Oct 14, 2019
    Depart – San Diego, California
    • At Sea
    • Cabo San Lucas, Mexico
    • At Sea
    • At Sea
    • Huatulco, Mexico
    • At Sea
    • At Sea
    • Fuerte Amador, Panama
    • At Sea
    • Manta, Ecuador
    • At Sea
    • Salaverry, Peru
    • Callao, Peru
    Returns – Callao, Peru
    San Diego, California - At Sea - Cabo San Lucas, Mexico - At Sea - At Sea - Huatulco, Mexico - At Sea - At Sea - Fuerte Amador, Panama - At Sea - Manta, Ecuador - At Sea - Salaverry, Peru - Callao, Peru - Callao, Peru
    Expedia® Extras* (Extras vary and apply to select staterooms and prices)
    • Save on Sunshine! Save up to 50% plus Suite guests receive FREE Internet!
    from
    C$1717*
    *restrictions apply
    Taxes of C$358 Included
  • 14-Night South America Cruise

    14-Night South America Cruise
    Celebrity Cruises
    Celebrity Eclipse
    Depart: Sun, Feb 2, 2020
    Returns: Sun, Feb 16, 2020
    Depart – Buenos Aires, Argentina
    • At Sea
    • At Sea
    • At Sea
    • Ushuaia, Argentina
    • Cape Horn, Chile
    • Schollart Channel, Antarctica
    • Paradise Bay / Errera Channel, Antarctica
    • Gerlache Strait, Antarctica
    • South Shetland Islands, Antarctica
    • At Sea
    • Port Stanley, Falkland Islands (Malvinas)
    • At Sea
    • Puerto Madryn, Argentina
    • At Sea
    • Montevideo, Uruguay
    Returns – Buenos Aires, Argentina
    Buenos Aires, Argentina - At Sea - At Sea - At Sea - Ushuaia, Argentina - Cape Horn, Chile - Schollart Channel, Antarctica - Paradise Bay / Errera Channel, Antarctica - Gerlache Strait, Antarctica - South Shetland Islands, Antarctica - At Sea - Port Stanley, Falkland Islands (Malvinas) - At Sea - Puerto Madryn, Argentina - At Sea - Montevideo, Uruguay - Buenos Aires, Argentina
    Expedia® Extras* (Extras vary and apply to select staterooms and prices)
    • Sail Your Way Savings Offer! Save up to $500 per stateroom!
    • Sail Plus! FREE Drinks & WiFi
    • Sail Plus! FREE Drinks & Tips
    • show more 
    from
    C$3375*
    *restrictions apply
    Taxes of C$372 Included

Terms & Conditions

*Expedia Extras offers are per stateroom (unless otherwise stated) on select sailings, based on double occupancy, apply to new bookings only, are not combinable with any other offer, are capacity controlled and may be withdrawn without notice. Certain restrictions may apply. For full terms and conditions, click the specific Expedia Extra offer or contact your Expedia CruiseShipCenters Vacation Consultant.

Prices are per person (based on 2 passengers in the same stateroom), cruise only in CAD dollars. Airfare, transfers, taxes, fees and port expenses are additional (unless otherwise stated). Prices vary by ship, stateroom type and sailing date. Prices and offers are subject to availability and change without notice, and are capacity controlled. Fuel supplement may apply. Expedia CruiseShipCenters is not responsible for errors that may occur due to the transfer of information from selected third parties, technical error, or human error.

Our default sort order is based on a number of relevant factors such as cruise line rating, ship rating, price per day, origin rating, destination rating, length of cruise, and booking window.